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SB 258585 hydrochloride

CAS No. 1216468-02-8

SB 258585 hydrochloride( SB258585 )

Catalog No. M10810 CAS No. 1216468-02-8

SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SB 258585 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM.
  • Description
    SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM, >160-fold selectivity over other 5-HT receptor subtypes; also is an inhibitor of HCV entry in liver-derived cell lines as well as primary hepatocytes, modulates localization of the coreceptor tight junction protein claudin-1 (CLDN1) in a 5-HT6-independent manner, induces intracellular accumulation of CLDN1.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SB258585
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1216468-02-8
  • Formula Weight
    523.814
  • Molecular Formula
    C18H23ClIN3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (238.63 mM)
  • SMILES
    CN1CCN(CC1)C2=C(C=CC(=C2)NS(=O)(=O)C3=CC=C(C=C3)I)OC.Cl
  • Chemical Name
    4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hirst WD, et al. Br J Pharmacol. 2000 Aug;130(7):1597-605. 2. Riva L, et al. J Virol. 2018 Apr 27;92(10). pii: e01982-17.
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