SB 258585 hydrochloride ( SB258585 )

Catalog No. M10810 CAS No. 1216468-02-8

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Product Name

SB 258585 hydrochloride
Note

Research use only, not for human use.
Brief Description

SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM.
Description

SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM, >160-fold selectivity over other 5-HT receptor subtypes; also is an inhibitor of HCV entry in liver-derived cell lines as well as primary hepatocytes, modulates localization of the coreceptor tight junction protein claudin-1 (CLDN1) in a 5-HT6-independent manner, induces intracellular accumulation of CLDN1.
Synonyms

SB258585
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

——
Indication

——

CAS Number

1216468-02-8
Formula Weight

523.81
Molecular Formula

C18H23ClIN3O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

CN1CCN(CC1)C2=C(C=CC(=C2)NS(=O)(=O)C3=CC=C(C=C3)I)OC.Cl
Chemical Name

4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide hydrochloride

1. Hirst WD, et al. Br J Pharmacol. 2000 Aug;130(7):1597-605.
2. Riva L, et al. J Virol. 2018 Apr 27;92(10). pii: e01982-17.

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